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CHOLESTEROL-LOWERING
DRUGS WITH INTERACTION
GOOD CHOLESTEROL
Cholesterol is needed in many important places in the human
body. In addition to its function as a stabilizer of the cell membrane, the
body's production of essential hormones is worth mentioning. These hormones,
made up of cholesterol, are the sex hormones such as progesterone, testosterone,
and estradiol with their diverse effects on muscle building, the menstrual
cycle, reproduction, and, in general, sexual function.
Cholesterol is formed in the adrenal glands, which is vital
and essential for our functioning. The body's cortisol for regulating blood
sugar and the dampening function of the immune system and aldosterone, with the
help of which blood pressure and salt excretion are adjusted, are produced
primarily in the adrenal cortex. Furthermore, the bile acids for fat absorption
in the small intestine consist of cholesterol structures. Finally, the starting
substance for vitamin D3 formation should be mentioned: 7-dehydro-cholesterol.
Without cholesterol, human and animal life is impossible.
KEY POINT
Many successive stations are involved in the process of
building up cholesterol. A long chain of metabolic steps is lined up like inflow
work. The central point is called HMG-CoA reductase, a biocatalyst. It is
precisely at this point that adjustments are made as required: it is adjusted
up when more cholesterol is needed, and it is reduced when enough is already
available.
STRESS
For example, to cope with strenuous physical or mental work,
the blood pressure and blood sugar are raised so that our muscles and brains
are adequately supplied with blood and sugar. Since the stress hormone cortisol
makes for a more extended adaptation, the starting substance cholesterol also
has to be replenished. So if the stress continues, blood cholesterol will rise.
Therefore, the biologically thinking doctor will recommend that his patient
with an elevated cholesterol level reflect on his stressors.
INHIBIT BIOSYNTHESIS: STATINS
The critical point in cholesterol synthesis now also serves
as a starting point for the cholesterol-lowering statins. This intervenes
directly in the body's regulation and inhibits production.
ADJACENT CONSTRUCTION SITE COENZYME Q10
Unfortunately, the critical point of cholesterol also
represents a key point for the build-up of coenzyme Q10. Its biosynthesis in
the human body uses the same route for a long time and is also reserved by
statins. Coenzyme Q10 is significantly involved in producing the body's energy.
Organs with the highest energy requirements also have the highest coenzyme Q10
concentration: muscles (heart!), Liver, and brain.
I cannot judge why the pharmaceutical manufacturers do not
automatically add coenzyme Q10, but I think it is due to the additional costs.
MUSCLE WEAKNESS
The most common undesirable side effect of statins is muscle
weakness - possibly due to a coenzyme Q10 deficiency. The large muscles' flaw
is particularly noticeable: climbing is more complicated, sore muscles exist
even without exertion. The muscle loss is medically objectified by measuring
the CPK (creatine phosphokinase, also CK for short) at the attending physician three
monthly.
INCREASE IN LIVER FUNCTION
When taking statins, a blood test of the liver values
should also be carried out every three months. From the above, it should be
clear why
RED RICE
There is an alternative to statins from naturopathic
cuisine: rice is fermented red using special mushrooms called Monascus
purpurea. It creates monacolin K or lovastatin—a natural cholesterol-lowering
option. Due to the natural occurrence, the pharmaceutical manufacturer cannot
apply for a patent. Red rice is currently classified as a dietary supplement
and can be freely sold. Therefore, nutritional supplement manufacturers can
refine the red rice recipes with additional substances.
BIOLOGICAL PREPARATIONS
The moral news is that apart from the conventional
pharmaceutical industry, there are already sensible combinations of
cholesterol-lowering red rice, to which sufficient coenzyme Q10 is already
added. I would estimate that 30mg coenzyme Q10 per day is mostly enough. Most
patients achieve good values with this. It also seems to me to be sensible to
take antioxidant protection, such as liver-protecting milk thistle.
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